Britney Spears, who made a shambolic "comeback" performance at last year's show, stands to win best female video for her hit single Piece Of Me.
She faces competition from Jordin Sparks, Katy Perry, Mariah Carey and R&B star Rihanna.
Among the male artists vying for a coveted moonman statuette are Lil Wayne, Chris Brown, Usher, TI and Flo Rida.
Categories to be announced in the coming weeks include video of the year, best rock video, best new artist and best dancing in a video.
On 6 November, the MTV Europe music awards take place at Liverpool's Echo Arena.
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